Health Policy

Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?

August, 2021

Highlights

  • Infection-enhancing antibodies have been detected in symptomatic Covid-19
  • Antibody dependent enhancement (ADE) is a potential concern for vaccines
  • Enhancing antibodies recognize both the Wuhan strain and Delta variants
  • ADE of Delta variants is a potential risk for current vaccines
  • Vaccine formulations lacking ADE epitope are suggested

Abstract

A TALE OF TWO SCIENTIFIC PARADIGMS: CONFLICTING SCIENTIFIC OPINIONS ON WHAT “FOLLOWING THE SCIENCE” MEANS FOR SARS-COV-2 AND THE COVID-19 PANDEMIC

August, 2021

DSA ADS Course - 2021

COVID19, Public Policy, Health Policy, Modeling, Model-driven Science, Empirically-driven Science, Lockdowns, Non-pharmaceutical Interventions, NPIs

Discuss 2 paradigms: Model-driven Science vs. Empirically-driven Science

Forecasting for COVID19 has Failed

June, 2020

DSA ADS Course - 2021

Forecasting, COVID19, John Ioannidis, Public Policy, Health Policy, Causal Inference, Forensic Medicine, Causality, Intuitive Causation, Probabilistic Causation

Forecasting is usually impossible in high causal density environments. Scenario planning with applied probability and adaptation to near real-time data is optimal strategy. Epidemic forecasting is usually a fools errand yet appropriate analysis of experience and historical precedent is helpful.

Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells

July, 2021

Highlights

  • Most recovered COVID-19 patients mount broad, durable immunity after infection
  • Neutralizing antibodies show a bi-phasic decay with half-lives >200 days
  • Spike IgG+ memory B cells increase and persist post-infection
  • Durable polyfunctional CD4 and CD8 T cells recognize distinct viral epitope regions

Summary

Pages